Amphetamine (AMP)
Amphetamine is a sympathomimetic amine with therapeutic indications. The drug is often self-administered by nasal inhalation or oral ingestion. Depending on the route of administration, amphetamine can be detected in oral fluid as early as 5-10 minutes following use.1 Amphetamine can be detected in oral fluid for up to 72 hours after use.
The Amphetamine assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the amphetamine concentration in oral fluid exceeds 50 ng/mL.
Cocaine (COC)
Cocaine is a potent CNS stimulant and a local anesthetic derived from the coca plant (erythroxylum coca). The drug is often self-administered by nasal inhalation, intravenous injection and free-base smoking. Depending on the route of administration, cocaine and its metabolites, benzoylecgonine and ecgonine methylester, can be detected in oral fluid as early as 5-10 minutes following use.1 Cocaine and benzoylecgonine can be detected in oral fluid for up to 24 hours after use
The Cocaine assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the cocaine metabolite concentration in oral fluid exceeds 20 ng/mL.
Opiates (OPI)
The drug class opiates refers to any drug that is derived from the opium poppy, including naturally occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and irritability. Opiates can be taken orally or by injection routes including intravenous, intramuscular and subcutaneous; illegal users may also take the drug intravenously or by nasal inhalation. Using an immunoassay cutoff level of 40 ng/mL, codeine can be detected in the oral fluid within 1 hour following a single oral dose and can remain detectable for 7-21 hours after the dose.2 6-Monoacetylmorphine (6-MAM) is found more prevalently in oral fluid, and is a metabolic product of heroin. Morphine is a major metabolic product of codeine and heroin, and is detectable for 24-48 hours following an opiate dose.
The Opiates assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the morphine concentration in oral fluid exceeds 40 ng/mL.
Marijuana (THC)
Tetrahydrocannabinol (THC), the active ingredient in the marijuana plant (cannabis sativa), is detectable in oral fluid shortly after use. The detection of the drug is thought to be primarily due to the direct exposure of the drug to the mouth (oral and smoking administrations) and the subsequent sequestering of the drug in the buccal cavity.3 Historical studies have shown a window of detection for THC in oral fluid of up to 14 hours after drug use.3
The THC assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the Δ9-THC concentration in oral fluid exceeds 100 ng/mL.
Phencyclidine (PCP)
Phencyclidine (PCP), the hallucinogen commonly referred to as Angel Dust, can be detected in oral fluid as a result of the exchange of the drug between the circulatory system and the oral cavity. In a paired serum and oral fluid sample collection of 100 patients in a hospital emergency department, PCP was detected in the oral fluid of 79 patients at levels as low as 2 ng/mL and as high as 600 ng/mL.
The Phencyclidine assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the PCP concentration in oral fluid exceeds 10 ng/mL.
Methamphetamine (mAMP)
Methamphetamine is a potent stimulant chemically related to amphetamine but with greater central nervous system (CNS) stimulation properties. The drug is often self-administered by nasal inhalation, smoking or oral ingestion. Depending on the route of administration, methamphetamine can be detected in oral fluid as early as 5-10 minutes following use.1 Methamphetamine can be detected in oral fluid for up to 72 hours after use.
The Methamphetamine assay contained within the OrALert™ Oral Fluid Drug Screen Device yields a positive result when the methamphetamine concentration in oral fluid exceeds 50 ng/mL.

The One Step Drug Screen Test Card is a lateral flow chromatographic immunoassay for the qualitative detection of multiple drugs and drug metabolites in urine at the following cut-off concentrations:

Analytical Specificity

The following tables lists the concentration of compounds (ng/mL) that are detected positive in urine by the One Step Drug Screen Test Card (Urine) at 5 minutes.